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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

In the IUCLID4 dataset on O,O-diethyl chlorothiophosphate, the results of several acute oral toxicity tests performed in rats are presented. The LD50 values are in the range of 953 - 1340 mg/kg bw/day.
Further information on the acute toxicity of O,O-diethyl chlorothiophosphate is provided in the IUCLID4 dataset of 2000. Acute inhalation toxicity studies revealed LC 50 values in the range of 0.154 – 0.615 mg/L after 4 hour exposure and of >2.137 mg/L after one hour exposure in rats. Acute dermal toxicity studies in rats resulted in LD50 values of 719 – 1439 mg/kg bw. Administration via intaperitoneal injection resulted in an LD50 of 170 mg/kg bw in mice.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
Value:
953 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Dose descriptor:
LC50
Value:
615 mg/m³ air

Acute toxicity: via dermal route

Endpoint conclusion
Dose descriptor:
LD50
Value:
719 mg/kg bw

Additional information

In the IUCLID4 dataset on O,O-diethyl chlorothiophosphate, the results of several acute oral toxicity tests performed in rats are presented. The LD50 values are in the range of 953 - 1340 mg/kg bw/day.

Further information on the acute toxicity of O,O-diethyl chlorothiophosphate is provided in the IUCLID4 dataset of 2000. Acute inhalation toxicity studies revealed LC 50 values in the range of 0.154 – 0.615 mg/L (154 - 615 mg/m3) after 4 hour exposure and of >2.137 mg/L after one hour exposure in rats. Acute dermal toxicity studies in rats resulted in LD50 values of 719 – 1439 mg/kg bw. Administration via intaperitoneal injection resulted in an LD50 of 170 mg/kg bw in mice.

Justification for classification or non-classification

Based on the results of the acute toxicity studies and taking into account the provisions laid down in Council Directive 67/548/EEC and CLP (1272/2008/EC), O,O-diethyl phosphorochloridothioate is classifed as toxic by inhalation and harmful if swallowed or by skin contact.