Registration Dossier
Registration Dossier
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EC number: 210-438-6 | CAS number: 615-60-1
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
48 hour LC50 (daphnia magna) = 2.01 mg/L (C.I. 1.59 - 2.74 mg/L), EC50 = 1.27 mg/L (C.I. 1.01 - 1.59 mg/L), OECD 202 (Boeri, 2004)
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 1.27 mg/L
Additional information
In the key study, the acute toxicity of the test material to Daphnia magna was determined in a 48 hour static test conducted in accordance with the OECD Guideline for Testing Chemicals, No. 202 under GLP conditions.
The nominal concentrations tested were 0.65, 1.1, 1.8, 3.0 and 5.0 mg/L, alongside a parallel control and a DMF solvent control.
Exposure of daphnids to 4-chloro-o-xylene resulted in a 48-hour median lethal concentration (LC50) of 2.01 mg/L (95 % confidence interval = 1.59 to 2.74 mg/L) and a 48‑hour median effective concentration (EC50) of 1.27 mg/L (95 % confidence interval = 1.01 to 1.59 mg/L). The 48-hour no observed effect concentration (NOEC) was 0.502 mg/L 4-chloro-o-xylene, the lowest tested concentration.
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