Brief Profile

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Please be aware that the REACH registration parts of this Brief Profile are no longer maintained; they remain frozen as of 19th May 2023. All other data parts (substance identity, C&L, key regulatory lists etc. are up to date).

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
201-245-8
CAS no.:
80-05-7
Index number:
604-030-00-0
Molecular formula:
C15H16O2
SMILES:
CC(C)(C1=CC=C(O)C=C1)C1=CC=C(O)C=C1
InChI:
InChI=1S/C15H16O2/c1-15(2,11-3-7-13(16)8-4-11)12-5-9-14(17)10-6-12/h3-10,16-17H,1-2H3
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
27
Of which contain:
1 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (ATP18) approved by the European Union, this substance may damage fertility, is very toxic to aquatic life, is very toxic to aquatic life with long lasting effects, causes serious eye damage, may cause an allergic skin reaction and may cause respiratory irritation.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance may damage fertility or the unborn child.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance is toxic to aquatic life with long lasting effects and is suspected of damaging fertility or the unborn child.

Breakdown of all 2592 C&L notifications submitted to ECHA

Eye Dam. 1 H318 Harmonised Classification
STOT SE 3 H335 Harmonised Classification
Skin Sens. 1 H317 Harmonised Classification
Repr. 2 H361
Repr. 1B H360F Harmonised Classification
Aquatic Chronic 2 H411
Aquatic Acute 1 H400 Harmonised Classification
Aquatic Chronic 1 H410 Harmonised Classification
Skin Sens. 1B H317
Aquatic Chronic 3 H412
STOT SE 3 H370
Asp. Tox. 1 H304
Muta. 1B H340
Carc. 1B H350
Ox. Sol. 3 H272
https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/more.png 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

  • R
Officially recognised in the EU as Toxic to Reproduction (Harmonised C&L, Candidate list of SVHCs).
  • R
There is broad agreement in that a majority of data submitters agree this substance is Toxic to Reproduction (100% of REACH registrations).
  • Ss
Officially recognised in the EU as Skin sensitising ( Harmonised C&L).
  • Ss
There is broad agreement in that a majority of data submitters agree this substance is Skin sensitising (100% of REACH registrations).
  • PBT
There is no overall agreement among data submitters, but a minority indicate they consider this substance as Persistent, Bioaccumulative and Toxic (1.37% of REACH registrations).
  • ED
Officially recognised in the EU as Endocrine Disrupting (Candidate list of SVHCs).
  • ED
Under assessment as Endocrine Disrupting (ED list).

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 66 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Substance included in the Community Rolling Action Plan (CoRAP).
Authorisation
Candidate List:
Substance of very high concern (SVHC) and included in the candidate list for authorisation.
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):
Some uses of this substance are restricted under Annex XVII of REACH.

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Seveso Annex I:
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 000 000 tonnes per annum.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

Other release to the environment of this substance is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment) and outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials).

This substance is used in the following activities or processes at workplace: the low energy manipulation of substances bound in materials or articles.

Other release to the environment of this substance is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment) and outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials).

This substance can be found in complex articles, with no release intended: machinery, mechanical appliances and electrical/electronic products (e.g. computers, cameras, lamps, refrigerators, washing machines) and vehicles. This substance can be found in products with material based on: plastic (e.g. food packaging and storage, toys, mobile phones).

This substance is used in the following products: polymers. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: plastic products and electrical, electronic and optical equipment.

This substance is used in the following activities or processes at workplace: transfer of chemicals, roller or brushing applications, mixing in open batch processes, transfer of substance into small containers, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure and treatment of articles by dipping and pouring.

Other release to the environment of this substance is likely to occur from: indoor use and outdoor use resulting in inclusion into or onto a materials (e.g. binding agent in paints and coatings or adhesives).

This substance is used in the following products: polymers. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following activities or processes at workplace: transfer of chemicals, transfer of substance into small containers and closed batch processing in synthesis or formulation.

Release to the environment of this substance can occur from industrial use: formulation of mixtures.

This substance is used in the following products: polymers. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: building & construction work, formulation of mixtures and/or re-packaging and scientific research and development. This substance is used for the manufacture of: plastic products, chemicals and machinery and vehicles.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, mixing in open batch processes and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates), in the production of articles, for thermoplastic manufacture and in processing aids at industrial sites.

This substance is used in the following activities or processes at workplace: closed, continuous processes with occasional controlled exposure, transfer of chemicals at dedicated facilities, transfer of substance into small containers and laboratory work.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: avoid release to the environment; avoid breathing the dust, fume, gas, mist, vapours or spray; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier.

Response statements

In case of incident: If exposed or concerned: get medical advice/attention. If on skin: wash with soap and water. If in eyes: rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • 3M Belgium BVBA/SPRL, Hermeslaan 7 1831 Diegem Belgium
  • 3M Wroclaw Sp.z.o.o., ul. Kowalska 143 51-424 Wroclaw Poland
  • AKZO Nobel Car Refinishes B.V., Rijksstraatweg 31 2170 BA Sassenheim Netherlands
  • Allnex Belgium NV/SA OR1, Anderlechtstraat 33 1620 Drogenbos Belgium
  • Allnex Italy S.R.L., Via Matteo Bianchin, 62 36060 Romano d'Ezzelino Italy
  • Axalta Coating Systems Germany GmbH & Co. KG, Christbusch 25 42285 Wuppertal Germany
  • BASF SE, Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany
  • BD&I_35, rue Omer Lepreux, 92 1081 bruxelles Belgium Belgium
  • Blue Cube Germany Assets GmbH & Co. KG, Buetzflether Sand 2 21683 Stade Germany
  • Blue Cube Netherlands B.V. – OR1, Axelsedam 3a 4531HH Terneuzen Netherlands
  • C.S.B. GmbH, Dujardinstr. 5 47829 Krefeld Germany
  • Caplinq Europe BV, De Trompet 1126 1967 DA Heemskerk - Netherlands
  • CCD (Germany) GmbH, Berliner Allee 55 40212 Düsseldorf Germany
  • ChampionX Europe B.V., Oude Rhijnhofweg 17 NL-2342BB Oegstgeest Oegstgeest Netherlands
  • Covestro Deutschland AG, Kaiser-Wilhelm-Allee 60 51373 Leverkusen Germany
  • Covestro Deutschland AG OR CN_001554, Kaiser-Wilhelm-Allee 60 51373 Leverkusen Germany
  • Covestro NV, Haven 507 Scheldelaan 420 2040 Antwerpen Belgium
  • CRCP GmbH, Am Römerhof 51 60486 Frankfurt am Main Germany
  • Cytec Engineered Materials GmbH in its legal capacity as OR of Cytec Industries Inc., Industriestraße 3 76684 Östringen Germany
  • Cytec Engineered Materials GmbH OR2, Industriestraße 3 76684 Östringen Germany
  • Du Pont de Nemours (Deutschland) GmbH, Hugenottenallee 175 D-63263 Neu-Isenburg Hesse Germany
  • Global Product Compliance (Europe) AB, IDEON, Beta 5, Scheelevägen 17, 22363 Lund Sweden
  • Henkel Global Supply Chain B.V., Gustav Mahlerlaan 2970 1081 LA Amsterdam Netherlands
  • Huntsman Advanced Materials (Europe) BV, Everslaan 45 B-3078 Everberg Belgium
  • Huntsman Advanced Materials (Europe) BV OR-USA, Everslaan 45 B-3078 Everberg Belgium
  • Idemitsu Chemicals Europe GmbH, Immermannstrasse 40 40210 Düsseldorf Germany
  • INEOS Composites Hispania S.L. (0341), Partida Povet, 37 ES-12580 Benicarlo Castellón de la Plana Spain
  • Kao Chemicals Europe, S.L. (10), Puig dels Tudons, 10 08210 Barbera del Valles Barcelona Spain
  • Kao Chemicals Europe, S.L. (2), Puig dels Tudons, 10 08210 Barbera del Valles Barcelona Spain
  • KTR Europe GmbH, Mergenthalerallee 77 65760 Eschborn Germany
  • Labcorp Development SA 155, Parque Empresarial Las Tablas, Edifico 1 Calle Federico Mompou, 5 - 5 Planta 28050 Madrid Spain
  • LG Chem Europe GmbH, Alfred Herrhausen Allee 3 5 D-65760 Eschborn Germany
  • Lubrizol Deutschland GmbH, Max-Planck-Strasse 6 27721 RITTERHUDE Germany
  • Lubrizol Europe Coordination Center BVBA 01, Chaussee De Wavre, 1945 1945 Brussels Belgium
  • Lubrizol Europe Coordination Center BVBA 02 , Chaussee De Wavre 1945 Brussels Belgium
  • Mitsui and Co. Deutschland G.M.B.H. Head Office (Düsseldorf), Herzogstrasse 15 D-40217 Düsseldorf Germany
  • Nalco Europe B.V., Oude Rhijnhofweg 17 2342 BB Oegstgeest Netherlands
  • PPG Coatings BV, Papesteeg 102 4006 WC Tiel Netherlands
  • PPG Europe B.V. - OR1, Amsterdamseweg 14 1422 AD Uithoorn Netherlands
  • PPG Europe B.V. - OR3, Amsterdamseweg 14 1422 AD Uithoorn Netherlands
  • REACHLaw Ltd., Vänrikinkuja 3 JK 21 FI-02600 Espoo Finland
  • Rondo Plast AB, Blygatan 6 27139 Ystad Sweden
  • RSI ChemRep Europe Ltd (I001), 27-30 Merchants Quay Merchants House 8 Dublin Ireland
  • RSI ChemRep Europe Ltd (M001), 27-30 Merchants Quay Merchants House 8 Dublin Ireland
  • RSI ChemRep Europe Ltd (M002), 27-30 Merchants Quay Merchants House 8 Dublin Ireland
  • RSI ChemRep Europe Ltd (M004), 27-30 Merchants Quay Merchants House 8 Dublin Ireland
  • RSI ChemRep Europe Ltd (N003), 27-30 Merchants Quay 8 Dublin Ireland
  • SABIC Innovative Plastics BV, Plasticslaan 1 4612 PX Bergen op Zoom Netherlands Netherlands
  • SABIC Innovative Plastics Espana ScpA, Ctra. Cartagena-Alhama de Murcia km. 13. La Aljorra 30390 Cartagena Spain Spain
  • SABIC Petrochemicals B.V., Europaboulevard 1 6135 LD Sittard Limburg Netherlands
  • SHPP B.V., Plasticslaan 1 4612PX Bergen op Zoom Netherlands
  • SI Group-Béthune S.A.S., 1111 Avenue George Washington Boite Postale 237 62404 Cedex Béthune France
  • Solvay Specialty Polymers Italy S.p.A., Viale Lombardia 20 20021 BOLLATE Italy
  • Spolek pro chemickou a hutní výrobu, a.s., Revoluční 1930/86 400 32 Ústí nad Labem Czech Republic
  • StonCor Europe, Rue du Travail, 9 1400 Nivelles Belgium
  • T-NET International (EU) GmbH, Rurtal Str. 33 41849 Wassenberg NRW Germany
  • Trinseo Deutschland Anlagengesellschaft mbH, Kölner Strasse 10 65760 Eschborn Germany
  • TsafeE GmbH, Landwehrpl 6 66111 Saarbrücken Germany
  • TÜV SÜD Iberia S.A.U. (003), Ronda Can Fatjó 13 08290 Cerdanyola del Vallès Barcelona Spain
  • TÜV SÜD Iberia S.A.U. (051), Ronda Can Fatjó 13 08290 Cerdanyola del Vallès Barcelona Spain
  • Westlake Epoxy B.V., Seattleweg 17, building 4 3195 ND Pernis-Rotterdam Netherlands
  • Westlake Epoxy B.V. OR, Seattleweg 17, Building 4 3195 ND Pernis-Rotterdam Netherlands
  • [Confidential], [Confidential]
  • Du Pont (U.K.) Limited, London Road 4th Floor, Kings Court SG1 2NG Stevenage Hertfordshire United Kingdom
  • EcoMole sro, U Vetrniku 40/1 16200 Praha Czech Republic
  • Huntsman Textile Effects (Germany) GmbH, Rehlinger Str. 1 D-86462 Langweid a.Lech Germany
  • PCC SYNTEZA SA, Szkolna 15 47-225 Kędzierzyn-Koźle opolskie Poland
  • RHODIA OPERATIONS - 1, 9 rue des Cuirassiers Immeuble Silex 2 Solvay 69003 Lyon France
  • Team-Trade, s.r.o., Rybničná 18/1 16200 Prague Czech Republic

Substance names and other identifiers

2,2-bis(4-hydroxyphenyl)propane
Other, FCM and Articles Regulation, Annex I - Authorised Substances, FCMs Recycled Plastic & Articles Regulation - Annex I - Authorised Use, Recycled Plastic FCMs - Regulation (EU) 2022/1616
4,4'-isopropylidenediphenol
EC Inventory, Candidate list, Substance Evaluation - CoRAP, REACH pre-registration
4,4'-Isopropylidenediphenol
Candidate list, Substance Evaluation - CoRAP, REACH pre-registration, Occupational Exposure Limits - 4th list - Indicative OELVs
4,4'-isopropylidenediphenol; bisphenol A
C&L Inventory
4.4’-Isopropylidenediphenol
CMD - Carcinogens and Mutagens Directive, Annex III - OELVs
Bisphenol A
Other, Cosmetic Products Regulation, Annex II - Prohibited Substances, , Occupational Exposure Limits - 4th list - Indicative OELVs, Toy Safety Directive - Substances Restricted in Toys, CMD - Carcinogens and Mutagens Directive, Annex III - OELVs
bisphenol A; 4,4'-isopropylidenediphenol
FCM Active and Intelligent Materials - CMRs not allowed for use, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Carc and Muta Directive, Annex I - Substances, Mixtures & Processes, Physical, Biological and Chemical Agents & Processes and Work
2-(2-méthoxyéthoxy)éthanol; éther monométhylique du diéthylène glycol (fr)
C&L Inventory
4,4'-isopropylideendifenol; bisfenol A (nl)
C&L Inventory
4,4’-isopropilidendifenol; bisfenol A; (mt)
C&L Inventory
4,4’-isopropilidenodifenol; bisfenol A (pt)
C&L Inventory
4,4’-isopropylidendifenol; bisfenol A (sv)
C&L Inventory
4,4’-Isopropylidendiphenol; Bisphenol A (de)
C&L Inventory
4,4’-izopropilidendifenol; bisfenol A (hr)
C&L Inventory
4,4’-izopropilidendifenol; bisfenol A (ro)
C&L Inventory
4,4’-izopropilidendifenol; bisfenol A (sl)
C&L Inventory
4,4’-izopropilidendifenolis; bisfenolis A (lt)
C&L Inventory
4,4’-izopropylidéndifenol; bisfenol A (sk)
C&L Inventory
4,4′-Isopropilidendifenol; bisfenol A (es)
C&L Inventory
4,4′-isopropilidendifenolo; bisfenolo A (it)
C&L Inventory
4,4′-isopropylideenidifenoli; bisfenoli A (fi)
C&L Inventory
4,4′-isopropylidendifenol; bisfenol A (cs)
C&L Inventory
4,4′-isopropylidendiphenol; bisphenol A (da)
C&L Inventory
4,4′-izopropilidén-difenol; biszfenol A (hu)
C&L Inventory
4,4′-izopropilidēndifenols bisfenols A (lv)
C&L Inventory
4,4′-izopropylidenodifenol; bisfenol A (pl)
C&L Inventory
4,4′-ισοπροπυλιδενοδιφαινόλη· δισφαινόλη Α (el)
C&L Inventory
4,4′-изопропилидендифенол; бисфенол A (bg)
C&L Inventory
bisfenol A 4,4'-isopropylidendifenol (no)
C&L Inventory
tribromo-2,2-dimetüülpropaan-1-ool; 3-bromo-2,2-bis(bromometüül)propaan-1-ool (et)
C&L Inventory
2,2-Bis(4-hydroxyphenyl) propane
Registration dossier
2,2-Bis(4-hydroxyphenyl)propane
C&L Inventory, Registration dossier
2.2-bis(4-hydroxyphenyl)propane
C&L Inventory
4,4' isopropylidenediphenol
C&L Inventory
4,4'-(1-Methylethyliden)bisphenol
C&L Inventory
4,4'-(propane-2,2-diyl)diphenol
C&L Inventory, Registration dossier
4,4'-dihydroxy-2,2-diphenylpropane
C&L Inventory
4,4'-Isopropylidendiphenol
C&L Inventory
4,4'-Isopropylidenebisphenol
C&L Inventory
4,4'-ISOPROPYLIDENEDIPHENOL
C&L Inventory
4,4'-isopropylidenediphenol
C&L Inventory, Registration dossier
4,4'-isopropylidenediphenol (Bisphenol-A)
C&L Inventory
4,4'-isopropylidenediphenol (CAS 80-05-7)
Registration dossier
4,4'-isopropylidenediphenolbisphenol A
C&L Inventory
4,4'-Propane-2,2-diyldiphenol
C&L Inventory, Registration dossier
4,4-isopropylidenediphenol
Registration dossier
4,4`-isopropylidenediphenol
C&L Inventory
4-[2-(4-hydroxyphenyl)propan-2-yl]phenol
C&L Inventory, Registration dossier, Other
4‐[2‐(4‐hydroxyphenyl)propan‐2‐yl]phenol
C&L Inventory
Bisfenol A (Difenylolpropan)
C&L Inventory
Bisphenol A
C&L Inventory
Bisphenol A
C&L Inventory, Registration dossier
bisphenol A 4,4'-isopropylidenediphenol
C&L Inventory
bisphenol A; 4,4'-isopropylidenediphenol
C&L Inventory
Bisphenol-A
Registration dossier
BPA
Registration dossier
Diphenylpropane, Bisphenol-A
Registration dossier
Phenol, 4,4 -(1-methylethylidene)bis-
C&L Inventory
Phenol, 4,4'-(1-methylethylidene)bis-
C&L Inventory
Phenol, 4,4'-isopropylidenedi-
C&L Inventory
4,4'-(1-Methylethylidene)bisphenol
Registration dossier
4,4'-Bisphenol A
Registration dossier
4,4'-Isopropylidendiphenol
Registration dossier
4,4'-Isopropylidenediphenol
Registration dossier
Bispenol- A
Registration dossier
Bisphenol
Registration dossier
Bisphenol A
C&L Inventory, Registration dossier
Bisphenol A - Polycarbonate grade
Registration dossier
Bisphenol A ER grade - Flake
Registration dossier
Bisphenol A; 4,4'-isopropylidenediphenol
C&L Inventory
BPA
Registration dossier
Diphenol methylethylidene
Registration dossier
Diphenylol propane
Registration dossier
DPP
Registration dossier
p,p'-Bisphenol A
Registration dossier
p,p'-Dihydroxydiphenylpropane
Registration dossier
p,p'-Isopropylidenebisphenol
Registration dossier
p,p'-Isopropylidenediphenol
Registration dossier
PARABIS(R) Resin intermediate
Registration dossier
Bisphenol A
Substance Evaluation - CoRAP
BPA
Substance Evaluation - CoRAP
137885-53-1
CAS number
Other
1429425-26-2
CAS number
Other
146479-75-6
CAS number
Other
27360-89-0
CAS number
Other
28106-82-3
CAS number
Other
37808-08-5
CAS number
Other
604-030-00-0
Index number
C&L Inventory
80-05-7
CAS number
EC Inventory, C&L Inventory, Candidate list, Substance Evaluation - CoRAP, Registration dossier, REACH pre-registration, Other, FCM Active and Intelligent Materials - CMRs not allowed for use, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, Cosmetic Products Regulation, Annex II - Prohibited Substances, , EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Occupational Exposure Limits - 4th list - Indicative OELVs, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, FCM and Articles Regulation, Annex I - Authorised Substances, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, General Product Safety Directive - Hazardous Substances, FCMs Recycled Plastic & Articles Regulation - Annex I - Authorised Use, Recycled Plastic FCMs - Regulation (EU) 2022/1616, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Toy Safety Directive - Substances Restricted in Toys, Waste Framework Directive, Annex III - Waste - Hazardous Properties, CMD - Carcinogens and Mutagens Directive, Annex III - OELVs, Carc and Muta Directive, Annex I - Substances, Mixtures & Processes, Physical, Biological and Chemical Agents & Processes and Work

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 1 study submitted
  • 1 study processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [1]
C Form
Other (100%) [1]
C Odour
Odourless (100%) [1]
C Substance type
Organic (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Solid (100%)
Form
Solid (100%)
Colour
white (100%)

Melting/freezing point

Study results
  • 7 studies submitted
  • 1 study processed
R Melting / freezing point
154 - 156.5 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 6
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Melting / freezing point at 101 325 Pa
155 °C

Boiling point

Study results
  • 4 studies submitted
  • 2 studies processed
R Boiling point
250 - 360 °C @ 17 - 1 013 hPa [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Boiling point at 101 325 Pa
360 °C

Density

Study results
  • 3 studies submitted
  • 1 study processed
R Relative density
1.2 @ 25 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Relative density at 20°C
1.2

Vapour pressure

Study results
  • 3 studies submitted
  • 1 study processed
R Vapour pressure
0 - 0 Pa @ 20 - 50 °C [3]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Vapour pressure
0 Pa @ 25 °C

Partition coefficient

Study results
  • 3 studies submitted
  • 1 study processed
R Log Pow
3.4 @ 21.5 °C and pH 6.4 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Log Kow (Log Pow)
3.4 @ 21.5 °C

Water solubility

Study results
  • 6 studies submitted
  • 1 study processed
R Water solubility (mass/vol.)
298 - 318 mg/L @ 25 °C and pH 7 - 8 [3]

Type of Study provided
Studies with data
Key study 1
Supporting study 1 4
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Water solubility
300 mg/L @ 25 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flash point

Study results
  • 4 studies submitted
  • 1 study processed
R Flash point
227 °C @ 101.3 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 2 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Flash point at 101 325 Pa
227 °C

Auto flammability

Study results
  • 4 studies submitted
  • 1 study processed
R Autoflammability / self-ignition
510 °C @ 101.3 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Autoflammability / self-ignition at 101 325 Pa
510 °C

Flammability

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Not classified (100%)

Explosiveness

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 3 studies submitted
  • 1 study processed
C Dissociating properties
Yes (100%) [1]
R Dissociation constant
11.3 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
pKa at 20 °C
11.3

Viscosity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 1 study submitted
  • 1 study processed
R Dissipation half life (DT50)
3.12 h [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half life in air
3.12 h
Degradation rate constant with OH radicals
0 cm³ molecule-1 d-1

Hydrolysis

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Phototransformation in water

Study results
  • 3 studies submitted
  • 1 study processed
R Dissipation Half-life (DT50)
17.4 - 235 h [4]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half-life in water
12 h

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 10 studies submitted
  • 2 studies processed
C Interpretation of results
Readily biodegradable (100%) [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 4
Weight of evidence
Other 4
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Readily biodegradable (100%)
Type of water
Freshwater (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 6
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation Factor (BCF) - L/kg ww
73 L/kg ww

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 13 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 6
Supporting study 2
Weight of evidence
Other 4 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Koc at 20°C
750

Henrys law constant (H)

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Henry's law constant
0 Pa.m³.mol-1 @ 25 °C

Distribution modelling

Study results
  • 7 studies submitted
  • 3 studies processed
% Distribution in Media:
R Air 0 - 0.01 % [3]
R Water 30.5 - 32.9 % [3]
R Soil 65.3 - 67.9 % [3]
R Sediment 1.51 - 1.8 % [3]
R Suspended sediment 0.05 % [1]
R Biota 0 % [1]

Type of Study provided
Studies with data
Key study 3
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 22.6 µg/L (1)
Intermittent releases (freshwater) 11 µg/L (1)
Marine water 19.3 µg/L (1)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 320 mg/L (1)
Sediment (freshwater) 1.2 mg/kg sediment dw (1)
Sediment (marine water) 240 µg/kg sediment dw (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 3.7 mg/kg soil dw (1)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (1)

Short–term toxicity to fish

Study results
  • 11 studies submitted
  • 3 studies processed
P/RResults
LC50 (4 days) 4.6 - 11 mg/L [4]
NOEC (4 days) 2.26 - 2.28 mg/L [2]

Type of Study provided
Studies with data
Key study 3
Supporting study 5
Weight of evidence
Other 3
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 23 studies submitted
  • 5 studies processed
P/RResults
NOEC (1.181 years) 16 µg/L [1]
NOEC (5.467 months) 130 - 567 µg/L [4]
NOEC (3.867 months) 66 - 250 µg/L [8]
NOEC (55 days) 250 µg/L [2]
NOEC (36 days) 640 µg/L [1]

Type of Study provided
Studies with data
Key study 5
Supporting study 9
Weight of evidence
Other 9
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 26 studies submitted
  • 3 studies processed
P/RResults
EC50 (4 days) 1.1 mg/L [1]
EC50 (48 h) 10.2 mg/L [1]
LC50 (4 days) 2.7 mg/L [1]
NOEC (4 days) 510 - 1 400 µg/L [2]

Type of Study provided
Studies with data
Key study 3
Supporting study 15
Weight of evidence
Other 8
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 23 studies submitted
  • 6 studies processed
P/RResults
NOEC (10.933 months) 25 µg/L [1]
NOEC (84 days) 640 µg/L [1]
NOEC (42 days) 490 µg/L [1]
NOEC (28 days) 170 - 370 µg/L [3]
NOEC (21 days) 3.146 mg/L [1]

Type of Study provided
Studies with data
Key study 6
Supporting study 10
Weight of evidence
Other 7
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 9 studies submitted
  • 2 studies processed
P/RResults
EC50 (4 days) 1.1 - 3.1 mg/L [4]
EC10 (4 days) 400 - 1 410 µg/L [3]

Type of Study provided
Studies with data
Key study 2
Supporting study 6
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for freshwater algae
2.73 mg/L
EC50 for marine water algae
1.1 mg/L
EC10 or NOEC for freshwater algae
1.41 mg/L
EC10 or NOEC for marine water algae
400 µg/L

Toxicity to aquatic plants other than algae

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
EC50 (7 days) 20 - 32 mg/L [3]
NOEC (7 days) 7.8 mg/L [1]
LOEC (7 days) 20 mg/L [1]
EC10 (7 days) 8.5 - 10.4 mg/L [2]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for freshwater plants
20 mg/L
EC10 or NOEC for freshwater plants
7.8 mg/L

Toxicity to microorganisms

Study results
  • 5 studies submitted
  • 2 studies processed
P/RResults
IC50 (16 h) 54.5 mg/L [1]
EC10 (18 h) 320 mg/L [1]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2
Other 3
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 or NOEC for microorganisms
320 mg/L

Sediment toxicity

Study results
  • 5 studies submitted
  • 3 studies processed
P/RResults
NOEC (28 days) 12 - 54 mg/kg sediment dw [4]
LOEC (28 days) 32 - 110 mg/kg sediment dw [4]
EC50 (28 days) 57 - 210 mg/kg sediment dw [3]
LC50 (28 h) 38 - 54 mg/kg sediment dw [3]

Type of Study provided
Studies with data
Key study 3
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 / LC50 for freshwater sediment
11 mg/kg sediment dw
EC10 / LC10 or NOEC for freshwater sediment
12 mg/kg sediment dw

Endocrine disrupter testing in aquatic vertebrates – in vivo

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
NOEC (60 days) 326 µg/L [1]
LOEC (60 days) 1.03 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No summary exists for this scientific endpoint

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 10 studies submitted
  • 1 study processed
P/RResults
NOEC (28 days) 100 mg/kg soil dw [1]
LC50 (28 days) 100 mg/kg soil dw [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 8
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Long-term EC10 / LC10 / NOEC
100 mg/kg soil dw

Toxicity to terrestrial arthropods

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
LC50 (28 days) 1 g/kg soil dw [1]
LOEC (28 days) 1 g/kg soil dw [1]
NOEC (28 days) 500 mg/kg soil dw [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Long-term EC10 / LC10 / NOEC
500 mg/kg soil dw

Toxicity to terrestrial plants

Study results
  • 4 studies submitted
  • 1 study processed
P/RResults
NOEC (21 days) 20 - 320 mg/kg soil dw [6]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Long-term EC10 / LC10 / NOEC
20 mg/kg soil dw

Toxicity to soil microorganisms

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to birds

Study results
  • 8 studies submitted
  • 1 study processed
P/RResults
NOEC (63 days) 1 000 mg/kg bw [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other 2 2
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Long-term EC10 / LC10 / NOEC
1 g/kg food

Toxicity to mammals

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 2 1
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 2 mg/m³ repeated dose toxicity
Acute /short term: (DNEL) 2 mg/m³ repeated dose toxicity
Local Effects
Long-term: (DNEL) 2 mg/m³ irritation (respiratory tract)
Acute /short term: (DNEL) 2 mg/m³ irritation (respiratory tract)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 66 µg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 66 µg/kg bw/day repeated dose toxicity
Local Effects
Long-term: (Medium hazard (no threshold derived)) -
Acute /short term: (Medium hazard (no threshold derived)) -
EYE Exposure
Medium hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1 mg/m³ repeated dose toxicity
Acute /short term: (DNEL) 1 mg/m³ repeated dose toxicity
Local Effects
Long-term: (DNEL) 1 mg/m³ irritation (respiratory tract)
Acute /short term: (DNEL) 1 mg/m³ irritation (respiratory tract)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 24 µg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 24 µg/kg bw/day repeated dose toxicity
Local Effects
Long-term: (Medium hazard (no threshold derived)) -
Acute /short term: (Medium hazard (no threshold derived)) -
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 53 µg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 53 µg/kg bw/day repeated dose toxicity
EYE Exposure
Medium hazard (no threshold derived)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 24 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 17 3
Supporting study 2
Weight of evidence
Other 2
Data waiving
no waivers
Study data: dermal absorption
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study 2 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation potential:
No bioaccumulation potential
Absorption values
Oral: 100 %
Dermal: 30 %
Inhalation: 100 %

Acute toxicity

Study results
oral
  • 2 studies submitted
  • 1 study processed
P/RResults
approx. LD50 2 000 - 5 000 mg/kg bw (rat) [1]

Type of Study provided
oral
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

inhalation
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
dermal
  • 2 studies submitted
  • 1 study processed
P/RResults
LD50 3 000 mg/kg bw (rabbit) [1]

dermal
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
Adverse effect observed LD50 4 100 mg/kg bw
Inhalation route:
Adverse effect observed Discriminating conc. 170 mg/m³ air
Dermal route:
Adverse effect observed LD50 3 000 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: eye
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
No adverse effect observed (not irritating)
Eye
Adverse effect observed (irritating)
Respiratory
Adverse effect observed (irritating)

Sensitisation

Study results
Study data: skin
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 1 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
Adverse effect observed (sensitising)
Respiratory sensitisation
No study available

Repeated dose toxicity

Study results
Study data: oral
  • 7 studies submitted
  • 3 studies processed
P/RResults
NOAEL (rat): 750 ppm [2]
NOAEL (mouse): 300 ppm [2]
LOAEL (rat): 600 mg/kg bw/day [1]
NOEL (rat): 75 ppm [1]
NOEL (mouse): 30 ppm [1]

Type of Study provided
Study data: oral
Studies with data
Key study 4
Supporting study 2 1
Weight of evidence
Other
Data waiving
no waivers
Study data: inhalation
  • 3 studies submitted
  • 2 studies processed
P/RResults
NOAEL (rat): 90 mg/m³ air [1]
NOEC (rat): 10 mg/m³ air [1]
LOEC (rat): 10 mg/m³ air [1]

Study data: inhalation
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route - systemic effects:
Adverse effect observed NOAEL 5 mg/kg bw/day (subchronic, mouse)
Inhalation route - systemic effects:
No adverse effect observed NOAEC 150 mg/m³ (subchronic, rat)
Inhalation route - local effects:
Adverse effect observed NOAEC 10 mg/m³ (subchronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: in vivo
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Toxicity - InVitro
No adverse effect observed (negative)
Toxicity - InVivo
No adverse effect observed (negative)

Carcinogenicity

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
No adverse effect observed NOAEL 25 mg/kg bw/day (chronic, rat)

Toxicity to reproduction

Study results
Study data: reproduction
  • 9 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 9
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: developmental
  • 19 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 11
Supporting study 6
Weight of evidence
Other 2
Data waiving
no waivers
Study data: other studies
  • 13 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other 13
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Effect on fertility
Oral route:
Adverse effect observed NOAEL 50 mg/kg bw/day (subchronic, rat)
Effect on developmental toxicity
Oral route:
Adverse effect observed NOAEL 640 mg/kg bw/day (subacute, rat)

Neurotoxicity

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
No adverse effect observed NOAEL 164 mg/kg bw/day (subchronic, rat)

Immunotoxicity

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
No adverse effect observed NOAEL 25 mg/kg bw/day (chronic, rat)

Endocrine disrupter mammalian screening - in vivo

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No summary exists for this scientific endpoint